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        谱天所骄傲的合作伙伴

         

        a.    蛋白质分析领域:谱天公司与世界顶级蛋白质分析中心有着紧密的合作和业务联系,如美国的NIH、耶鲁医学院、瑞士的苏黎世联邦工学院等著名研究机构,以及美国的Anaspec、德国的JPT等蛋白生物公司。谱天公司还是美国知名蛋白质谱分析专家Balgley博士名下的Bioproximity企业的兄弟公司。谱天的国际合作保证了核心技术与世界同步。

         

        临床疾病分析领域:为了获取高质量临床样本进行质谱分析,谱天公司与美国耶鲁大学医学院、杜克大学医学院、德国弗赖堡医学院、韩国首尔三星医学院,以及国内的首都医科大学天坛医院、复旦大学华山医院、天津医科大学总医院、哈尔滨医科大学、南京医科大学、山西医科大学、中山医科大学、香港大学等著名临床医学单位建立了合作伙伴关系。


        2014年成立以来其他奖励证书

        2015年与天津国际生物医药联合研究院成立分析测试中心临床质谱检测平台

        2014年天津市科委癌症重大专项

        2014年天津市人才绿色通道项目
         

        Our Proteomics-related Publications

        1. 

        1. Vogel TW, Zhuang Z, Li J, Okamoto H, Furuta M, Lee YS, et al. Proteins and protein pattern differences between glioma cell lines and glioblastoma multiforme. Clin Cancer Res. 2005;11:3624-32.
        2. Wang Y, Rudnick PA, Evans EL, Li J, Zhuang Z, Devoe DL, et al. Proteome analysis of microdissected tumor tissue using a capillary isoelectric focusing-based multidimensional separation platform coupled with ESI-tandem MS. Anal Chem. 2005;77:6549-56.
        3. Glasker S, Li J, Xia JB, Okamoto H, Zeng W, Lonser RR, et al. Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell. Cancer Res. 2006;66:4167-72.
        4. Li J, Yin C, Okamoto H, Jaffe H, Oldfield EH, Zhuang Z, et al. Proteomic analysis of inclusion body myositis. J Neuropathol Exp Neurol. 2006;65:826-33.
        5. Li J, Zhuang Z, Okamoto H, Vortmeyer AO, Park DM, Furuta M, et al. Proteomic profiling distinguishes astrocytomas and identifies differential tumor markers. Neurology. 2006;66:733-6.
        6. Lubensky IA1, Vortmeyer AO, Kim S, Lonser RR, Park DM, Ikejiri B, Li J, et al. Identification of tumor precursor cells in the brains of primates with radiation-induced de novo glioblastoma multiforme. Cell Cycle. 2006;5:452-6.
        7. Li J, Okamoto H(equal contrib)Vortmeyer AO, Jaffe H, Lee YS, Glasker S, et al. Comparative proteomic profiles of meningioma subtypes. Cancer Res. 2006;66:10199-204.
        8. Glasker S, Lonser RR, Okamoto H, Li J, Jaffee H, Oldfield EH, et al. Proteomic profiling: a novel method for differential diagnosis? Cancer Biol Ther. 2007;6:343-5.
        9. Guo T, Wang W, Rudnick PA, Song T, Li J, Zhuang Z, et al. Proteome analysis of microdissected formalin-fixed and paraffin-embedded tissue specimens. J Histochem Cytochem. 2007;55:763-72.
        10. Li J, Okamoto H(equal contrib), Glasker S, Vortmeyer AO, Jaffe H, Robison RA, et al. Proteomic comparison of oligodendrogliomas with and without 1pLOH. Cancer Biol Ther. 2007;6:391-6.
        11. Park DM, Li J, Okamoto H, Akeju O, Kim SH, Lubensky I, et al. N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation. Cell Cycle. 2007;6:467-70.
        12. Li J, Okamoto H, Yin C, Jagannathan J, Takizawa J, Aoki S, et al. Proteomic characterization of primary diffuse large B-cell lymphomas in the central nervous system. J Neurosurg. 2008;109:536-46.
        13. Li J, Yin C, Okamoto H, Mushlin H, Balgley BM, Lee CS, et al. Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas. Neuro Oncol. 2008;10:45-51.
        14. Jagannathan J, Li J, Szerlip N, Vortmeyer AO, Lonser RR, Oldfield EH, et al. Application and implementation of selective tissue microdissection and proteomic profiling in neurological disease. Neurosurgery. 2009;64:4-14
        15. Helgager J, Li J, Lubensky IA, Lonser R, Zhuang Z. Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents. J Oncol. 2010;2010:373491.
        16. Zhuang Z, Qi M, Li J, Okamoto H, Xu DS, Iyer RR, et al. Proteomic identification of glutamine synthetase as a differential marker for oligodendrogliomas and astrocytomas. J Neurosurg. 2011 Oct;115(4):789-95.
        17. Chen Z, Wang Q, Lin L, Tang Q, Edwards JL, Li S, Liu S. Comparative evaluation of two isobaric labeling tags, DiART and iTRAQ. Anal Chem. 2012 Mar 20;84(6):2908-15.
        18. Li J, Kil C, Considine K, Smarkucki B, Stankewich MC, Balgley B, et al. Intrinsic indicators for specimen degradation. Lab Invest. 2013 Feb;93(2):242-53.
        19. Clark VE1, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, Avşar T, Li J, Murray PB, Henegariu O, et al. Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO. Science. 2013 Mar 1;339(6123):1077-80. 
        20. Chen Z, Wen B, Wang Q, Tong W, Guo J, Bai X, Zhao J, Sun Y, Tang Q, Lin Z, Lin L, Liu S. Quantitative proteomics reveals the temperature-dependent proteins encoded by a series of cluster genes in thermoanaerobacter tengcongensis. Mol Cell Proteomics. 2013 Aug;12(8):2266-77.
        21. Song J, Sun R, Li D, Tan F, Li X, Jiang P, Huang X, Lin L, Deng Z, Zhang Y. An improvement of shotgun proteomics analysis by adding next-generation sequencing transcriptome data in orange. PLoS One. 2012;7(6):e39494.
        22. Wu Q, Xu W, Cao L, Li X, He T, Wu Z, Li W. SAHA treatment reveals the link between histone lysine acetylation and proteome in nonsmall cell lung cancer A549 Cells. J Proteome Res. 2013 Sep 6;12(9):4064-73.
        23. Liao G, Xie L, Li X, Cheng Z, Xie J. Unexpected extensive lysine acetylation in the trump-card antibiotic producer Streptomyces roseosporus revealed by proteome-wide profiling. J Proteomics. 2014 Jun 25;106:260-9.
        24. Liu X, Zhao L, Yang Y, Bode L, Huang H, Liu C, Huang R, Zhang L, Wang X, Zhang L, Liu S, Zhou J, Li X, He T, Cheng Z, Xie P. Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells. Virology. 2014 Sep;464-465:196-205.